Generation of anti-factor Xa active, 3-O-sulfated glucosamine-rich sequences by controlled desulfation of oversulfated heparins.

@article{Naggi2001GenerationOA,
  title={Generation of anti-factor Xa active, 3-O-sulfated glucosamine-rich sequences by controlled desulfation of oversulfated heparins.},
  author={Annamaria Naggi and B De Cristofano and Antonella Bisio and Giangiacomo Torri and Benito Casu},
  journal={Carbohydrate research},
  year={2001},
  volume={336 4},
  pages={
          283-90
        }
}
Controlled release of 2, 3 desulfated heparin exerts its anti-inflammatory activity by effectively inhibiting E-selectin.
TLDR
The steady state concentration of 2, 3 DSH was found to be optimal to elicit anti-inflammatory property and could achieve inhibition of E-selectin expression while unaffecting the normal clotting cascade.
Heparin derivatives as inhibitors of BACE-1, the Alzheimer's beta-secretase, with reduced activity against factor Xa and other proteases.
TLDR
The derivative with the highest anti-BACE-1 to anti-Xa activity ratio contained N-acetyl and 2- O- and 6-O-sulfates and also exhibited attenuated activities against cathepsin-D and renin, two other structurally related aspartyl proteases.
Chemical Derivatization of Sulfated Glycosaminoglycans
TLDR
This review surveys reactions on the basis of the sulfated GAG substrate and the sort of structural modification (sulfation pattern modification, oxidation, carboxy group derivatization, N- and O-acylation, reducing-end functionalization) that are reported in the last two decades.
Inhibitory effects of glycosaminoglycans on basal and stimulated transforming growth factor-β1 expression in mesangial cells: biochemical and structural considerations.
TLDR
Judging from the investigation, chondroitin sulfates seem the most promising for potential pharmacological applications in disorders characterized by fibrogenic TGF-β1 overexpression.
Glycomics approach to structure-function relationships of glycosaminoglycans.
TLDR
This review highlights the important aspects of GAGs and summarizes these aspects in the context of taking a glycomics approach that integrates the different technologies to define structure-function relationships of G AGs.
Disruption of rosetting in Plasmodium falciparum malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities.
TLDR
In this study, inhibitors of rosetting by the Plasmodium falciparum strain R-29, based on chemically modified heparin polysaccharides and their depolymerized, low molecular weight derivatives were identified with reduced anticoagulant and protease activities.
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