Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen.

@article{Chen2004GenerationOA,
  title={Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen.},
  author={Tse-Ching Chen and Stephen Paul Cobbold and Paul Jonathan Fairchild and Herman Waldmann},
  journal={Journal of immunology},
  year={2004},
  volume={172 10},
  pages={5900-7}
}
Regulatory CD4(+) T cells are known to develop during the induction of donor-specific peripheral tolerance to transplanted tissues; it is proposed that such tolerance is a consequence of persistent, danger-free stimulation by Ag. To test this hypothesis, male RAG-1(-/-) mice were recolonized with small numbers of monospecific CD4(+) T cells specific for the male H-2E(k)-restricted Ag Dby. After 6 wk in the male environment, the monospecific CD4(+) T cells, having recolonized the host, had… CONTINUE READING

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