Generation of an osteoblast-based artificial niche that supports in vitro B lymphopoiesis

@inproceedings{Yu2017GenerationOA,
  title={Generation of an osteoblast-based artificial niche that supports in vitro B lymphopoiesis},
  author={Jiyeon Yu and Seunga Choi and Hyeonkyeong Kim and Nari Lee and Hyeongseok Yun and Sumi Kim and Seong-Tae Jeong and Jaerang Rho},
  booktitle={Experimental & molecular medicine},
  year={2017}
}
B lymphocytes are produced from hematopoietic stem cells (HSCs) through the highly ordered process of B lymphopoiesis, which is regulated by a complex network of cytokines, chemokines and cell adhesion molecules derived from the hematopoietic niche. Primary osteoblasts function as an osteoblastic niche (OBN) that supports in vitro B lymphopoiesis. However, there are significant limitations to the use of primary osteoblasts, including their relative scarcity and the consistency and efficiency of… CONTINUE READING