Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H266.

@article{Marthaler2016GenerationOA,
  title={Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H266.},
  author={Adele G Marthaler and Alisa Tubsuwan and Benjamin Schmid and Ulla B Poulsen and Alexander F. Engelbrecht and Ulrike Mau-Holzmann and Poul Maddox Hyttel and Troels Tolstrup Nielsen and J\orgen E. Nielsen and Bj\orn Holst},
  journal={Stem cell research},
  year={2016},
  volume={16 1},
  pages={202-5}
}
Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease primarily affecting the cerebellum. Very little is known about the molecular mechanisms underlying the disease and, to date, no cure or treatment is available. We have successfully generated bona fide induced pluripotent stem cell (iPSC) lines of SCA2 patients in order to study a disease… CONTINUE READING