Generation of an immortalized erythroid progenitor cell line from peripheral blood: A model system for the functional analysis of Plasmodium spp. invasion

@article{Scully2019GenerationOA,
  title={Generation of an immortalized erythroid progenitor cell line from peripheral blood: A model system for the functional analysis of Plasmodium spp. invasion},
  author={Erik J Scully and E. Shabani and Gabriel W Rangel and Christof Gr{\"u}ring and Usheer Kanjee and M. Clark and Mudit Chaand and R. Kurita and Yukio Nakamura and Marcelo U. Ferreira and M. Duraisingh},
  journal={American Journal of Hematology},
  year={2019},
  volume={94},
  pages={963 - 974}
}
Malaria pathogenesis is caused by the replication of Plasmodium parasites within the red blood cells (RBCs) of the vertebrate host. This selective pressure has favored the evolution of protective polymorphisms in erythrocyte proteins, a subset of which serve as cognate receptors for parasite invasion ligands. Recently, the generation of RBCs from immortalized hematopoietic stem cells (HSCs) has offered a more tractable system for genetic manipulation and long‐term in vitro culture, enabling… Expand
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