Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C.

@article{Garcion2004GenerationOA,
  title={Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C.},
  author={Emmanuel Garcion and Aida Halilagic and Andreas Faissner and Charles ffrench-Constant},
  journal={Development},
  year={2004},
  volume={131 14},
  pages={3423-32}
}
Stem cells in the embryonic mammalian CNS are initially responsive to fibroblast growth factor 2 (FGF2). They then undergo a developmental programme in which they acquire epidermal growth factor (EGF) responsiveness, switch from the production of neuronal to glial precursors and become localized in specialized germinal zones such as the subventricular zone (SVZ). Here we show that extracellular matrix molecules act as regulators of this programme. Tenascin C is highly expressed in the SVZ, and… CONTINUE READING
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