Generation of an HLA-restricted cytotoxic T cell line reactive against cultured tumor cells from a patient infected with human T cell leukemia/lymphoma virus

@article{Mitsuya1983GenerationOA,
  title={Generation of an HLA-restricted cytotoxic T cell line reactive against cultured tumor cells from a patient infected with human T cell leukemia/lymphoma virus},
  author={Hiroaki Mitsuya and LouisA. Matis and Mary Megson and PaulA. Bunn and Clifford Murray and Derrick L. Mann and Robert C. Gallo and Samuel E Broder},
  journal={The Journal of Experimental Medicine},
  year={1983},
  volume={158},
  pages={994 - 999}
}
Lymphocytes from a patient who had an unusually long survival after therapy for a human T cell leukemia/lymphoma virus (HTLV)-associated T cell lymphoma were stimulated in vitro with an autologous tumor cell line, and the generation of cytotoxic T lymphocytes (CTL) was studied. CTL generated were directed against autologous (HTLV-associated tumor cells. These propagated CTL were OKT3+, OKT4-, and OKT8+. The cytotoxic activity required target tumor cells that were infected with HTLV and also… CONTINUE READING

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