Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector.

@article{Walker2012GenerationOA,
  title={Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector.},
  author={Jon E Walker and Rachel X Chen and Jeannine Logan McGee and Catherine Ann Nacey and Richard B. Pollard and Mehrdad Abedi and Gerhard Bauer and Jan A Nolta and Joseph S. Anderson},
  journal={Journal of virology},
  year={2012},
  volume={86 10},
  pages={5719-29}
}
HIV gene therapy has the potential to offer an alternative to the use of current small-molecule antiretroviral drugs as a treatment strategy for HIV-infected individuals. Therapies designed to administer HIV-resistant stem cells to an infected patient may also provide a functional cure, as observed in a bone marrow transplant performed with hematopoietic stem cells (HSCs) homozygous for the CCR5-Δ32-bp allele. In our current studies, preclinical evaluation of a combination anti-HIV lentiviral… CONTINUE READING
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