Generation of alternative Ultrabithorax isoforms and stepwise removal of a large intron by resplicing at exon-exon junctions.

@article{Hatton1998GenerationOA,
  title={Generation of alternative Ultrabithorax isoforms and stepwise removal of a large intron by resplicing at exon-exon junctions.},
  author={Anthony Hatton and V Subramaniam and Alberto J L{\'o}pez},
  journal={Molecular cell},
  year={1998},
  volume={2 6},
  pages={787-96}
}
Little is known about mechanisms that regulate and ensure accurate processing of complex transcription units with long introns. We investigate this in the Ultrabithorax gene of Drosophila. A consensus 5' splice site is regenerated at the junction between the first exon and a small internal exon (mI); this splice site is used in a developmentally regulated manner to remove mI during subsequent processing of the downstream intron. Conserved elements within mI and an interaction with exon mII… CONTINUE READING

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