Generation of allocation sequences in randomised trials: chance, not choice

@article{Schulz2002GenerationOA,
  title={Generation of allocation sequences in randomised trials: chance, not choice},
  author={K. Schulz and D. Grimes},
  journal={The Lancet},
  year={2002},
  volume={359},
  pages={515-519}
}
The randomised controlled trial sets the gold standard of clinical research. However, randomisation persists as perhaps the least-understood aspect of a trial. Moreover, anything short of proper randomisation courts selection and confounding biases. Researchers should spurn all systematic, non-random methods of allocation. Trial participants should be assigned to comparison groups based on a random process. Simple (unrestricted) randomisation, analogous to repeated fair coin-tossing, is the… Expand
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