Generation of aggregated beta-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits.

@article{Stphan2001GenerationOA,
  title={Generation of aggregated beta-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits.},
  author={Aline St{\'e}phan and Serge Laroche and Sabrina Davis},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 15},
  pages={
          5703-14
        }
}
  • Aline Stéphan, Serge Laroche, Sabrina Davis
  • Published in
    The Journal of neuroscience…
    2001
  • Biology, Medicine
  • We injected a combination of the beta-amyloids (Abetas) Abeta40 and Abeta43 to "seed" formation of amyloid deposits in the dorsal dentate gyrus of rats in vivo, on the basis of a theory of Jarrett and Landsbury (1993). Rats were tested on several different learning tasks, and synaptic transmission and plasticity were assessed in vivo. Between 7 and 16 weeks after injection, we found aggregated amyloid material, reactive astrocytosis, microgliosis, and cell loss around the sites of injection… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 120 CITATIONS, ESTIMATED 63% COVERAGE

    What can rodent models tell us about cognitive decline in alzheimer’s disease?

    VIEW 11 EXCERPTS
    CITES BACKGROUND

    Disruption of Persistent Nociceptive Behavior in Rats with Learning Impairment

    VIEW 4 EXCERPTS
    CITES METHODS & BACKGROUND
    HIGHLY INFLUENCED

    Alzheimer amyloid peptide aβ42 regulates gene expression of transcription and growth factors.

    VIEW 5 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Decreased rhythmic GABAergic septal activity and memory-associated theta oscillations after hippocampal amyloid-beta pathology in the rat.

    VIEW 5 EXCERPTS
    CITES BACKGROUND, METHODS & RESULTS

    FILTER CITATIONS BY YEAR

    2002
    2020

    CITATION STATISTICS

    • 5 Highly Influenced Citations

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 74 REFERENCES

    The molecular pathology of Alzheimer's disease

    VIEW 4 EXCERPTS
    HIGHLY INFLUENTIAL

    Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state.

    VIEW 6 EXCERPTS
    HIGHLY INFLUENTIAL

    Selective loss of hippocampal granule cells following adrenalectomy: implications for spatial memory.

    VIEW 4 EXCERPTS
    HIGHLY INFLUENTIAL