Generation of adenosyl radical from S-adenosylmethionine (SAM) in biotin synthase.


A mechanism of the C-S bond activation of S-adenosylmethionine (SAM) in biotin synthase is discussed from quantum mechanical/molecular mechanical (QM/MM) computations. The active site of the enzyme involves a [4Fe-4S] cluster, which is coordinated to the COO(-) and NH(2) groups of the methionine moiety of SAM. The unpaired electrons on the iron atoms of the… (More)
DOI: 10.1016/j.jinorgbio.2011.03.013


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