Generation of a prostate from a single adult stem cell

  title={Generation of a prostate from a single adult stem cell},
  author={K. G. Leong and B. Wang and L. Johnson and W. Gao},
  • K. G. Leong, B. Wang, +1 author W. Gao
  • Published 2008
  • Biology, Medicine
  • Nature
  • The existence of prostate stem cells (PSCs) was first postulated from the observation that normal prostate regeneration can occur after repeated cycles of androgen deprivation and replacement in rodents. Given the critical role of PSCs in maintaining prostate tissue integrity and their potential involvement in prostate tumorigenesis, it is important to define specific markers for normal PSCs. Several cell-surface markers have been reported to identify candidate PSCs, including stem cell antigen… CONTINUE READING
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    • 41
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    • L. Xin, D. Lawson, O. Witte
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    • Proceedings of the National Academy of Sciences of the United States of America
    • 2005
    • 413
    • PDF
    Prostatic stem cell marker identified by cDNA microarray in mouse.
    • 19
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    • 252
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