Generation of a porcine alveolar macrophage cell line for the growth of porcine reproductive and respiratory syndrome virus.

@article{Lee2010GenerationOA,
  title={Generation of a porcine alveolar macrophage cell line for the growth of porcine reproductive and respiratory syndrome virus.},
  author={Yoo Jin N. Lee and Choi-Kyu Park and Eeuri Nam and Seong-Hee Kim and O-Soo Lee and Du Sik Lee and Changhee Lee},
  journal={Journal of virological methods},
  year={2010},
  volume={163 2},
  pages={410-5}
}
Porcine reproductive and respiratory syndrome virus (PRRSV) has a marked tropism for cells of the monocyte-macrophage lineage and accordingly, replicates in fully differentiated alveolar macrophages in the natural host. Despite the identification of several putative receptors for PRRSV on porcine alveolar macrophages (PAM), only CD163 was found to be able to make non-permissive cells susceptible to PRRSV, indicating a requirement for CD163 in productive infection. Interestingly, the preliminary… CONTINUE READING

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