Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells--a potential mechanism for targeting liver anti-fibrotic therapeutics.

@article{Elrick2005GenerationOA,
  title={Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells--a potential mechanism for targeting liver anti-fibrotic therapeutics.},
  author={L. Elrick and Val Leel and M. Blaylock and L. Duncan and M. Drever and G. Strachan and K. Charlton and M. Koruth and Andrew J. Porter and M. Wright},
  journal={Journal of hepatology},
  year={2005},
  volume={42 6},
  pages={
          888-96
        }
}
  • L. Elrick, Val Leel, +7 authors M. Wright
  • Published 2005
  • Biology, Medicine
  • Journal of hepatology
  • BACKGROUND/AIMS Hepatic stellate cells are pivotal to fibrogenesis in the liver and many potential anti-fibrotic therapeutics are required to act on targets within hepatic stellate cells. The aim of this study was to generate a human antibody fragment to hepatic stellate cells. METHODS Phage display was used to generate a human monoclonal antibody fragment to a peptide sequence present on an extracellular domain of synaptophysin, a protein expressed on the surface of hepatic stellate cells… CONTINUE READING
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