Generation of a minimal alpha5beta1 integrin-Fc fragment.


The tertiary structure of the integrin heterodimer is currently unknown, although several predictive models have been generated. Detailed structural studies of integrins have been consistently hampered for several reasons, including the small amounts of purified protein available, the large size and conformational flexibility of integrins, and the presence… (More)


Cite this paper

@article{Coe2001GenerationOA, title={Generation of a minimal alpha5beta1 integrin-Fc fragment.}, author={Anne Coe and J. Askari and Aaron Kline and Michael K. Robinson and Hishani Kirby and P Eileen Stephens and Martin J Humphries}, journal={The Journal of biological chemistry}, year={2001}, volume={276 38}, pages={35854-66} }