Generation of a human melanocyte cell line by introduction of HPV16 E6 and E7 genes

  title={Generation of a human melanocyte cell line by introduction of HPV16 E6 and E7 genes},
  author={I. Caroline Le Poole and Frank M. van den Berg and Ren{\'e} M. J. G. J. van den Wijngaard and Denise A. Galloway and Peter J. van Amstel and Anita A. M. Buffing and Henk L. Smits and Wiete Westerhof and Pranab Kumar Das},
  journal={In Vitro Cellular & Developmental Biology - Animal},
Availability of a standard human melanocyte cell line with unlimited growth potential and otherwise normal melanocytic properties will greatly facilitate research in melanocyte biology and in vitro studies on the etiology of pigmentary disorders and melanoma. Using a retroviral vector, E6 and E7 open reading frames of human papilloma virus type 16 (HPV 16) have been introduced into cultured normal human melanocytes. Cells selected by increased resistance to geneticin conveyed by the vector and… CONTINUE READING
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Emergence of c~sl33 fibronectin- and cq!33 vitronectin receptor expression in melanocytic tumor progression

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