Generation of a human anti-idiotypic antibody that mimics the GD2 antigen.

@article{Saleh1993GenerationOA,
  title={Generation of a human anti-idiotypic antibody that mimics the GD2 antigen.},
  author={M. N. Saleh and J D Stapleton and Muhamad B. Khazaeli and Albert F Lobuglio},
  journal={Journal of immunology},
  year={1993},
  volume={151 6},
  pages={3390-8}
}
In a phase 1 trial, patients with metastatic melanoma received the anti-GD2 murine mAb 14G2a. All patients developed human anti-14G2a antibodies including anti-Id antibodies. Peripheral blood MNCs from one such patient were fused with the murine myeloma cell line Ag8. Four human anti-14G2a secreting hybridomas were generated and the mAb product of one of… CONTINUE READING

Topics

Statistics

050100'97'99'01'03'05'07'09'11'13'15'17
Citations per Year

142 Citations

Semantic Scholar estimates that this publication has 142 citations based on the available data.

See our FAQ for additional information.