Generation of a genomic reporter assay system for analysis of γ- and β-globin gene regulation.


A greater understanding of the regulatory mechanisms that govern γ-globin expression in humans, especially the switching from γ- to β-globin, which occurs after birth, would help to identify new therapeutic targets for patients with β-hemoglobinopathy. To further elucidate the mechanisms involved in γ-globin expression, a novel fluorescent-based cellular… (More)
DOI: 10.1096/fj.11-199356


7 Figures and Tables