Generation of a catalytic module on a self-folding RNA.

  title={Generation of a catalytic module on a self-folding RNA.},
  author={Wataru Yoshioka and Yoshiya Ikawa and Luc Jaeger and Hideaki Shiraishi and Tan Inoue},
  volume={10 12},
It is theoretically possible to obtain a catalytic site of an artificial ribozyme from a random sequence consisting of a limited numbers of nucleotides. However, this strategy has been inadequately explored. Here, we report an in vitro selection technique that exploits modular construction of a structurally constrained RNA to acquire a catalytic site for RNA ligation from a short random sequence. To practice the selection, a sequence of 30 nucleotides was located close to the putative reaction… CONTINUE READING

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