Generation of a Fibrin Based Three-Layered Skin Substitute

  title={Generation of a Fibrin Based Three-Layered Skin Substitute},
  author={Johanna Kober and Alfred Gugerell and Melanie Schmid and L P Kamolz and Maike Keck},
  booktitle={BioMed research international},
A variety of skin substitutes that restore epidermal and dermal structures are currently available on the market. However, the main focus in research and clinical application lies on dermal and epidermal substitutes whereas the development of a subcutaneous replacement (hypodermis) is often disregarded. In this study we used fibrin sealant as hydrogel scaffold to generate a three-layered skin substitute. For the hypodermal layer adipose-derived stem cells (ASCs) and mature adipocytes were… CONTINUE READING

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In vitro adipogenesis of adipose-derived stem cells in 3D fibrin matrix of low component concentration.

Journal of tissue engineering and regenerative medicine • 2012
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Autologous skin substitute for hard-to-heal ulcers: retrospective analysis on safety, applicability, and efficacy in an outpatient and hospitalized setting.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society • 2013

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