Generation of T cell growth factor (TCGF)- dependent splenic lymphoid cell line with cell-mediated immunosuppressive reactivity against syngeneic murine tumor.

@article{Koyama1985GenerationOT,
  title={Generation of T cell growth factor (TCGF)- dependent splenic lymphoid cell line with cell-mediated immunosuppressive reactivity against syngeneic murine tumor.},
  author={Syohei Koyama and Takayuki Yoshioka and Takao Sakita and Shigeyoshi Fujimoto},
  journal={European journal of cancer & clinical oncology},
  year={1985},
  volume={21 2},
  pages={257-61}
}
Splenic T cells obtained from tumor-bearing mice could be cultured with T cell growth factor (TCGF) for over 12 months. The TCGF-dependent lymphoid cell line strongly inhibited cell-mediated anti-tumor immunity directed against syngeneic tumor. However, the suppression was non-specific for the given tumor. The cell line expanded with TCGF expressed a phenotypic characterization of T cells defined by monoclonal anti-Thy-1.2 antibody.