Generation of Silent Synapses by Acute In Vivo Expression of CaMKIV and CREB

@article{Marie2005GenerationOS,
  title={Generation of Silent Synapses by Acute In Vivo Expression of CaMKIV and CREB},
  author={H{\'e}l{\`e}ne Marie and Wade Morishita and Xiang Yu and Nicole Calakos and Robert C Malenka},
  journal={Neuron},
  year={2005},
  volume={45},
  pages={741-752}
}
The transcription factor CREB is critical for several forms of experience-dependent plasticity in a range of species and is commonly activated in neurons by calcium/calmodulin-dependent protein kinase IV (CaMKIV). Surprisingly, little is known about the neural circuit adaptations caused by activation of CaMKIV and CREB. Here, we use viral-mediated gene transfer in vivo to examine the consequences of acute expression of constitutively active forms of CaMKIV and CREB on synaptic function in the… CONTINUE READING
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