Corpus ID: 24097421

Generation of Reactive Oxygen Radicals through Bioactivation of Mitomycin Antibiotics 1

@inproceedings{Pritsos2006GenerationOR,
  title={Generation of Reactive Oxygen Radicals through Bioactivation of Mitomycin Antibiotics 1},
  author={C. Pritsos and A. Sartorelli},
  year={2006}
}
Mitomycin C (MC) is a naturally occurring anticancer agent which has been shownto be more cytotoxicto hypoxictumor cells than to their aerobic counterparts. The mechanism of action of this agent is thought to involvebiologicalreductiveactivation,to a speciesthat alkylutes DNA. A comparisonof the cytotoxicityof MC to EMT6 tumor cells with that of the structural analogues porfiromycin(PM), .•V-(,V',Ai"-diiiielhylaniinomethylene)amineanalogueof mitomycinC (BMY-25282),and ;\'-(.!\", .V'-ilimeth… Expand

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