Generation of Pathogenic Th17 Cells in the Absence of TGF-β Signaling

  title={Generation of Pathogenic Th17 Cells in the Absence of TGF-β Signaling},
  author={Kamran Ghoreschi and Arian D J Laurence and Xiang-Ping Yang and Cristina M. Tato and Mandy J McGeachy and Joanne E Konkel and Hayde{\'e} L. Ramos and Lai Wei and Todd Scott Davidson and Nicolas Bouladoux and John R Grainger and Qian Chen and Yuka Kanno and Wendy T Watford and Hong-wei Sun and G{\'e}rard Eberl and Ethan M Shevach and Yasmine Belkaid and Daniel J. Cua and Wanjun Chen and John J. O’Shea},
CD4+ T-helper cells that selectively produce interleukin (IL)-17 (TH17), are critical for host defence and autoimmunity. Although crucial for TH17 cells in vivo, IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and transforming growth factor (TGF)-β1 have been proposed to be the factors responsible for initiating specification. Here we show that TH17 differentiation can occur in the absence of TGF-β signalling. Neither IL-6 nor IL-23 alone efficiently… CONTINUE READING
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