Generation of PEGylated VPAC1-selective antagonists that inhibit proliferation of a lung cancer cell line.

@article{Pan2008GenerationOP,
  title={Generation of PEGylated VPAC1-selective antagonists that inhibit proliferation of a lung cancer cell line.},
  author={Clark Qun Pan and Sarah Hamren and Steve Roczniak and Irene Tom and Mary E Derome},
  journal={Peptides},
  year={2008},
  volume={29 3},
  pages={479-86}
}
Vasoactive intestinal peptide (VIP) binds to two receptors, VPAC1 and VPAC2. Non-selective VIP antagonists have been shown to inhibit human cancer cell proliferation and reduce tumor growth in mice. Many human cancers over-express VPAC1 but not VPAC2. We show that VPAC1-selective antagonists can inhibit human cancer cell proliferation and identify five… CONTINUE READING