Generation of Novel Thyroid Cancer Stem-Like Cell Clones: Effects of Resveratrol and Valproic Acid.

@article{Hardin2016GenerationON,
  title={Generation of Novel Thyroid Cancer Stem-Like Cell Clones: Effects of Resveratrol and Valproic Acid.},
  author={Heather A Hardin and Xiao-min Yu and April D. Harrison and Carolina Larra{\'i}n and Ranran Zhang and Jidong Chen and Herbert C Chen and Ricardo Vincent Lloyd},
  journal={The American journal of pathology},
  year={2016},
  volume={186 6},
  pages={
          1662-73
        }
}
Anaplastic thyroid cancer is an aggressive and highly lethal cancer for which conventional therapies have proved ineffective. Cancer stem-like cells (CSCs) represent a small fraction of cells in the cancer that are resistant to chemotherapy and radiation therapy and are responsible for tumor reoccurrence and metastasis. We characterized CSCs in thyroid carcinomas and generated clones of CSC lines. Our study showed that anaplastic thyroid cancers had significantly more CSCs than well… CONTINUE READING
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