Generation of Novel Single-Chain Antibodies by Phage-Display Technology to Direct Imaging Agents Highly Selective to Pancreatic β- or α-Cells In Vivo

@inproceedings{Ueberberg2009GenerationON,
  title={Generation of Novel Single-Chain Antibodies by Phage-Display Technology to Direct Imaging Agents Highly Selective to Pancreatic β- or α-Cells In Vivo},
  author={Sandra Ueberberg and Juris J Meier and Carmen W{\"a}ngler and Wolfgang Schechinger and Johannes Wolfgang Christian Dietrich and Andrea Tannapfel and Inge Schmitz and Ralf Schirrmacher and Manfred K{\"o}ller and Hermann H. Klein and Stephan Schneider},
  booktitle={Diabetes},
  year={2009}
}
OBJECTIVE Noninvasive determination of pancreatic beta-cell mass in vivo has been hampered by the lack of suitable beta-cell-specific imaging agents. This report outlines an approach for the development of novel ligands homing selectively to islet cells in vivo. RESEARCH DESIGN AND METHODS To generate agents specifically binding to pancreatic islets, a phage library was screened for single-chain antibodies (SCAs) on rat islets using two different approaches. 1) The library was injected into… CONTINUE READING

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