Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family.

@article{Uyama2012GenerationON,
  title={Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family.},
  author={Toru Uyama and Natsuki Ikematsu and Manami Inoue and Naoki Shinohara and Xing-Hua Jin and Kazuhito Tsuboi and Takeharu Tonai and Akira Tokumura and Natsuo Ueda},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 38},
  pages={31905-19}
}
Bioactive N-acylethanolamines (NAEs), including N-palmitoylethanolamine, N-oleoylethanolamine, and N-arachidonoylethanolamine (anandamide), are formed from membrane glycerophospholipids in animal tissues. The pathway is initiated by N-acylation of phosphatidylethanolamine to form N-acylphosphatidylethanolamine (NAPE). Despite the physiological importance of this reaction, the enzyme responsible, N-acyltransferase, remains molecularly uncharacterized. We recently demonstrated that all five… CONTINUE READING
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