Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

@inproceedings{Gerdemann2011GenerationOM,
  title={Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant},
  author={Ulrike Gerdemann and Juan A. Fuentes Vera and Cliona M Rooney and Ann M. Leen},
  booktitle={Journal of visualized experiments : JoVE},
  year={2011}
}
Viral infections cause morbidity and mortality in allogeneic hematopoietic stem cell transplant (HSCT) recipients. We and others have successfully generated and infused T-cells specific for Epstein Barr virus (EBV), cytomegalovirus (CMV) and Adenovirus (Adv) using monocytes and EBV-transformed lymphoblastoid cell (EBV-LCL) gene-modified with an adenovirus vector as antigen presenting cells (APCs). As few as 2x10(5)/kg trivirus-specific cytotoxic T lymphocytes (CTL) proliferated by several logs… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

Vaccination Targeting Native Receptors to Enhance the Function and Proliferation of Chimeric Antigen Receptor (CAR)-Modified T Cells.

Miyuki Tanaka, Haruko Tashiro, +9 authors Cliona M Rooney
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2017
VIEW 5 EXCERPTS

References

Publications referenced by this paper.
SHOWING 1-10 OF 22 REFERENCES

vectors utilizing a novel RNA based plasmid selection system

J. A. Williams, J. Luke, L. Johnson, C. Hodgson
  • 2009