Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming.

@article{Miura2017GenerationOM,
  title={Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming.},
  author={Shizuka Miura and Atsushi Suzuki},
  journal={Cell stem cell},
  year={2017},
  volume={21 4},
  pages={456-471.e5}
}
Intestinal organoids hold great promise as a valuable tool for studying and treating intestinal diseases. The currently available sources of human intestinal organoids, tissue fragments or pluripotent stem cells, involve invasive procedures or complex differentiation protocols, respectively. Here, we show that a set of four transcription factors, Hnf4… CONTINUE READING