Generation of Mouse and Human Induced Pluripotent Stem Cells (iPSC) from Primary Somatic Cells

@article{Lorenzo2012GenerationOM,
  title={Generation of Mouse and Human Induced Pluripotent Stem Cells (iPSC) from Primary Somatic Cells},
  author={I. Lorenzo and Aarne Fleischer and Daniel Bachiller},
  journal={Stem Cell Reviews and Reports},
  year={2012},
  volume={9},
  pages={435-450}
}
Cellular reprogramming consists of the conversion of differentiated cells into pluripotent cells; the so-called induced Pluripotent Stem Cells. iPSC are amenable to in vitro manipulation and, in theory, direct production of any differentiated cell type. Furthermore, iPSC can be obtained from sick individuals and subsequently used for disease modeling, drug discovery and regenerative treatments. iPSC production was first achieved by transducing, with the use of retroviral vectors, four specific… 

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