Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

@article{Soldner2011GenerationOI,
  title={Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations},
  author={Frank Soldner and Jos{\'e}e Lagani{\`e}re and Albert Wu Cheng and Dirk Hockemeyer and Qing Gao and Raaji K. Alagappan and Vikram Khurana and Lawrence I. Golbe and Richard H. Myers and Susan Lindquist and Lei Zhang and Dmitry Guschin and Lauren K. Fong and B. Joseph Vu and Xiangdong Meng and Fyodor D. Urnov and Edward J. Rebar and Philip D. Gregory and Huanda Steve Zhang and Rudolf Jaenisch},
  journal={Cell},
  year={2011},
  volume={146},
  pages={318-331}
}
Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease, as well as a promising source for cell replacement therapies. One crucial limitation has been the inability to perform experiments under genetically defined conditions. This is particularly relevant for late age onset disorders in which in vitro phenotypes are predicted to be subtle and susceptible to significant effects of genetic background variations. By… CONTINUE READING
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