Generation of Intermediate Porcine iPS Cells Under Culture Condition Favorable for Mesenchymal-to-Epithelial Transition

@article{Zhang2014GenerationOI,
  title={Generation of Intermediate Porcine iPS Cells Under Culture Condition Favorable for Mesenchymal-to-Epithelial Transition},
  author={Shiqiang Zhang and Yanjie Guo and Yi Cui and Yajun Liu and Tong Yu and Huayan Amy Wang},
  journal={Stem Cell Reviews and Reports},
  year={2014},
  volume={11},
  pages={24-38}
}
It has been demonstrated that naïve and primed pluripotency are determined by different extracellular signals. In this study, we investigated whether intermediate pluripotent states could be available by manipulating the culture condition during the process of generating pig induced pluripotent stem cells (piPSCs). By optimizing the culture condition that efficiently promotes mesenchymal-to-epithelial transition (MET), we found that combination of three growth factors (LIF, FGF2 and BMP4) and… CONTINUE READING
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