Generation of Humoral Immune Responses to Multi-Allele PfAMA1 Vaccines; Effect of Adjuvant and Number of Component Alleles on the Breadth of Response

@inproceedings{Kusi2010GenerationOH,
  title={Generation of Humoral Immune Responses to Multi-Allele PfAMA1 Vaccines; Effect of Adjuvant and Number of Component Alleles on the Breadth of Response},
  author={Kwadwo A Kusi and Bart W Faber and Vanessa Riasat and Alan W. Thomas and Clemens H. M. Kocken and Edmond Joseph Remarque},
  booktitle={PloS one},
  year={2010}
}
There is increasing interest in multi-allele vaccines to overcome strain-specificity against polymorphic vaccine targets such as Apical Membrane Antigen 1 (AMA1). These have been shown to induce broad inhibitory antibodies in vitro and formed the basis for the design of three Diversity-Covering (DiCo) proteins with similar immunological effects. The antibodies produced are to epitopes that are shared between vaccine alleles and theoretically, increasing the number of component AMA1 alleles is… CONTINUE READING
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