Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice

@inproceedings{Becker2010GenerationOH,
  title={Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice},
  author={Pablo D Becker and Nicolas Legrand and Caroline M. M. van Geelen and Miriam Noerder and Nicholas D Huntington and Annick Lim and Etsuko Yasuda and Sean A Diehl and Ferenc A Scheeren and Michael H. Ott and Kees C Weijer and Heiner Wedemeyer and James P Di Santo and T. Beaumont and Carlos Alberto Guzm{\'a}n and Hergen Spits},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Passive transfer of antibodies not only provides immediate short-term protection against disease, but also can be exploited as a therapeutic tool. However, the 'humanization' of murine monoclonal antibodies (mAbs) is a time-consuming and expensive process that has the inherent drawback of potentially altering antigenic specificity and/or affinity. The immortalization of human B cells represents an alternative for obtaining human mAbs, but relies on the availability of biological… CONTINUE READING
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