Generation of H-2-restricted cytotoxic T cells by ultraviolet light-treated trinitrophenyl-modified syngeneic cells: increased requirement for adherent cells.


Metabolically inactive (ultraviolet light- [UV] irradiated) cells are incapable of serving as allogeneic stimulators in a mixed lymphocyte reaction (MLR). The reason for the requirement of metabolic activity is not known. Now we have used UV-irradiated, trinitrophenyl- (TNP) coupled syngeneic spleen cells as stimulators in vitro to generate TNP-specific… (More)


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