Generation of Germline-Competent Rat Induced Pluripotent Stem Cells

  title={Generation of Germline-Competent Rat Induced Pluripotent Stem Cells},
  author={Sanae Hamanaka and Tomoyuki Yamaguchi and Toshihiro Kobayashi and Megumi Kato-Itoh and Satoshi Yamazaki and Hideyuki Sato and Ayumi Umino and Yukiko Wakiyama and Mami Arai and Makoto Sanbo and Masumi Hirabayashi and Hiromitsu Nakauchi},
  booktitle={PloS one},
BACKGROUND Recent progress in rat pluripotent stem cell technology has been remarkable. Particularly salient is the demonstration that embryonic stem cells (ESCs) in the rat (rESCs) can contribute to germline transmission, permitting generation of gene-modified rats as is now done using mouse ESCs (mESCs) or mouse induced pluripotent stem cells (iPSCs; miPSCs). However, determinations of whether rat iPSCs (riPSCs) can contribute to germ cells are not published. Here we report the germline… CONTINUE READING


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Animal Biotechnology 2

Springer International Publishing • 2018


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Generation of genetically modified rats from embryonic stem cells.

Proceedings of the National Academy of Sciences of the United States of America • 2010
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