Generation of Functional Human Retinal Ganglion Cells with Target Specificity from Pluripotent Stem Cells by Chemically Defined Recapitulation of Developmental Mechanism.

@article{Teotia2017GenerationOF,
  title={Generation of Functional Human Retinal Ganglion Cells with Target Specificity from Pluripotent Stem Cells by Chemically Defined Recapitulation of Developmental Mechanism.},
  author={Pooja Teotia and Divyan A Chopra and Shashank Manohar Dravid and Matthew J Van Hook and Fang Qiu and J. Calvin Morrison and Angie Rizzino and Iqbal Ahmad},
  journal={Stem cells},
  year={2017},
  volume={35 3},
  pages={572-585}
}
Glaucoma is a complex group of diseases wherein a selective degeneration of retinal ganglion cells (RGCs) lead to irreversible loss of vision. A comprehensive approach to glaucomatous RGC degeneration may include stem cells to functionally replace dead neurons through transplantation and understand RGCs vulnerability using a disease in a dish stem cell model. Both approaches require the directed generation of stable, functional, and target-specific RGCs from renewable sources of cells, that is… CONTINUE READING

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