Generation of F1 hybrid cytotoxic T lymphocytes specific for self H-2.

Abstract

Cytotoxic T lymphocytes specific for self H-2 antigens are generated by murine F1 hybrid (H-2 heterozygous) spleen cells cultured with irradiated parental (H-2 homozygous) splenocytes. The effectors bind to heterozygous and homozygous cells bearing the appropriate H-2 alleles but only lyse homozygous targets. Autoreactivity for membrane-bound molecules of… (More)

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Cite this paper

@article{Nakano1981GenerationOF, title={Generation of F1 hybrid cytotoxic T lymphocytes specific for self H-2.}, author={Kiichiroh Nakano and Ichiro Nakamura and Gustavo Cudkowicz}, journal={Nature}, year={1981}, volume={289 5798}, pages={559-63} }