Generation of DNA base modification following treatment of cultured murine keratinocytes with benzoyl peroxide.

@article{King1996GenerationOD,
  title={Generation of DNA base modification following treatment of cultured murine keratinocytes with benzoyl peroxide.},
  author={J K King and Patricia A. Egner and Thomas W Kensler},
  journal={Carcinogenesis},
  year={1996},
  volume={17 2},
  pages={
          317-20
        }
}
  • J K King, Patricia A. Egner, Thomas W Kensler
  • Published in Carcinogenesis 1996
  • Biology, Medicine
  • Benzoyl peroxide (BzPO) is a free radical generating compound that acts as a tumor promoter and progressor in mouse skin. BzPO is cleaved in the presence of copper to produce benzoyloxyl and phenyl radicals. Treatment of mutation reporter plasmids with BzPO and copper yields predominantly single-strand breaks and G-->T transversion mutations. To explore the role of base modifications in the possible mammalian mutagenicity of BzPO the formation of 8-hydroxy-2'-deoxyguanosine (8-OHdG) within the… CONTINUE READING

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