Generation of Cytotoxic Lymphocytes in Mixed Lymphocyte Reactions

  title={Generation of Cytotoxic Lymphocytes in Mixed Lymphocyte Reactions},
  author={J. M. A. Forman and G{\"o}ran M{\"o}ller},
  journal={The Journal of Experimental Medicine},
  pages={672 - 685}
MLC were established to test for the generation of specific cytotoxic effector cells in CML. The target cell used to assay for CML in the five combinations tested was of a differentH-2 haplotype from the stimulating cell population. Cytotoxicity was observed against this target only when it shared private alloantigens (antigens that are specific for theH-2D andH-2K region of differentH-2 haplotypes) with the stimulating cell population. Very weak or no Cytotoxicity was found when such… CONTINUE READING

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