Generation of CD8+ and CD4+ T-cell response to dendritic cells genetically engineered to express the MART-1/Melan-A gene.

@article{PerezDiez1998GenerationOC,
  title={Generation of CD8+ and CD4+ T-cell response to dendritic cells genetically engineered to express the MART-1/Melan-A gene.},
  author={Ainhoa Perez-Diez and Lisa H Butterfield and Luke Li and Nitya G. Chakraborty and James Steven Economou and Bijay Mukherji},
  journal={Cancer research},
  year={1998},
  volume={58 23},
  pages={5305-9}
}
Both CD8+ and CD4+ T cells have demonstrated roles in antitumor immune response in many animal tumor systems. In many human tumor systems, although abundant literature exists on the evidence of tumor antigen-specific CD8+ CTL response, only limited information is available on tumor antigen-specific CD4+ T-cell response. Using the MART-1/Melan-A (MART-1) antigen system as a prototype human tumor-associated antigen (TAA)- and dendritic cell (DC)-based MART-1 antigen presentation system (i.e., DCs… CONTINUE READING

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