Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.

@article{Beher2002GenerationOC,
  title={Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.},
  author={Dirk Beher and Jonathan D Wrigley and Andrew P Owens and Mark S. Shearman},
  journal={Journal of neurochemistry},
  year={2002},
  volume={82 3},
  pages={563-75}
}
Aberrant production of amyloid-beta peptides by processing of the beta-amyloid precursor protein leads to the formation of characteristic extracellular protein deposits which are thought to be the cause of Alzheimer's disease. Therefore, inhibiting the key enzymes responsible for amyloid-beta peptide generation, beta- and gamma-secretase may offer an opportunity to intervene with the progression of the disease. In human brain and cell culture systems a heterogeneous population of amyloid-beta… CONTINUE READING

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