Generation of Amyloid-β Is Reduced by the Interaction of Calreticulin with Amyloid Precursor Protein, Presenilin and Nicastrin

@inproceedings{Stemmer2013GenerationOA,
  title={Generation of Amyloid-β Is Reduced by the Interaction of Calreticulin with Amyloid Precursor Protein, Presenilin and Nicastrin},
  author={Nina Stemmer and Elena Strekalova and Nevena Djogo and Frank Ploeger and Gabriele Loers and David Lutz and Friedrich Buck and Marek Michalak and Melitta Schachner and Ralf Kleene},
  booktitle={PloS one},
  year={2013}
}
Dysregulation of the proteolytic processing of amyloid precursor protein by γ-secretase and the ensuing generation of amyloid-β is associated with the pathogenesis of Alzheimer's disease. Thus, the identification of amyloid precursor protein binding proteins involved in regulating processing of amyloid precursor protein by the γ-secretase complex is essential for understanding the mechanisms underlying the molecular pathology of the disease. We identified calreticulin as novel amyloid precursor… CONTINUE READING