Generation-dependent encapsulation/electrostatic attachment of phenobarbital molecules by poly(amidoamine) dendrimers: Evidence from 2D-NOESY investigations.

@article{Cheng2009GenerationdependentEA,
  title={Generation-dependent encapsulation/electrostatic attachment of phenobarbital molecules by poly(amidoamine) dendrimers: Evidence from 2D-NOESY investigations.},
  author={Yiyun Cheng and Yiwen Li and Qinglin Wu and Jiahai Zhang and Tongwen Xu},
  journal={European journal of medicinal chemistry},
  year={2009},
  volume={44 5},
  pages={
          2219-23
        }
}
The interactions of phenobarbital with different generations of amine-terminated poly(amidoamine) (PAMAM) dendrimers were investigated by using two dimensional-nuclear Overhauser effect spectroscopic (2D-NOESY) investigations. The NOESY spectra clearly showed that there were cross-peaks from NOE interactions between the protons of phenobarbital and the protons in interior cavities of generation 5 or generation 6 PAMAM dendrimers but none of such cross-peaks was found in the case of generation 3… CONTINUE READING
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