Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

  title={Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery},
  author={R. Houghten and C. Pinilla and S. Blondelle and J. Appel and C. Dooley and J. Cuervo},
  • R. Houghten, C. Pinilla, +3 authors J. Cuervo
  • Published 1991
  • Biology, Medicine
  • Nature
  • EXISTING methods for the synthesis and screening of large numbers of peptides are limited by their inability to generate and screen the requisite number (millions) of individual peptides1–4 and/or their inability to generate unmodified free peptides in quantities able to interact in solution4–8. We have circumvented these limitations by developing synthetic peptide combinatorial libraries composed of mixtures of free peptides in quantities which can be used directly in virtually all existing… CONTINUE READING
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