Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic

  title={Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic},
  author={Ben Jackson and Maciej F. Boni and Matthew J. Bull and Amy Colleran and Rachel M. Colquhoun and Alistair C. Darby and Sam T. Haldenby and Verity Hill and Anita O. Lucaci and John T. McCrone and Samuel M. Nicholls and {\'A}ine Niamh O'toole and Nicole Pacchiarini and Radoslaw Poplawski and Emily Scher and Flora Todd and Hermione J. Webster and Mark A Whitehead and Claudia Wierzbicki and Nicholas James Loman and Thomas Richard Connor and David L. Robertson and Oliver G. Pybus and Andrew Rambaut},
  pages={5179 - 5188.e8}
We present evidence for multiple independent origins of recombinant SARS-CoV-2 viruses sampled from late 2020 and early 2021 in the United Kingdom. Their genomes carry single nucleotide polymorphisms and deletions that are characteristic of the B.1.1.7 variant of concern, but lack the full complement of lineage-defining mutations. Instead, the remainder of their genomes share contiguous genetic variation with non-B.1.1.7 viruses circulating in the same geographic area at the same time as the… Expand

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