Generation and transcriptional programming of intestinal dendritic cells: Essential role of retinoic acid

@inproceedings{Zeng2016GenerationAT,
  title={Generation and transcriptional programming of intestinal dendritic cells: Essential role of retinoic acid},
  author={Ruizhu Zeng and Michael Bscheider and Katharina Lahl and Mike Y. J. Lee and Eugene C. Butcher},
  booktitle={Mucosal immunology},
  year={2016}
}
The vitamin A metabolite retinoic acid (RA) regulates adaptive immunity in the intestines, with well-characterized effects on IgA responses, Treg induction, and gut trafficking of T- and B-effector cells. It also controls the generation of conventional dendritic cell (cDC) precursors in the bone marrow and regulates cDC subset representation, but its roles in the specialization of intestinal cDC subsets are understudied. Here we show that RA acts cell intrinsically in developing gut-tropic pre… CONTINUE READING
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