Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies.

  title={Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies.},
  author={Heinz Hillen and Stefan Barghorn and Andreas Striebinger and Boris Labkovsky and Reinhold Mueller and Volker Nimmrich and Marc W Nolte and Claudia Perez-Cruz and Ingrid van der Auwera and Fred van Leuven and Marcel M. van Gaalen and Anton Y. Bespalov and Hans Schoemaker and James P. Sullivan and Ulrich Ebert},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={30 31},
Oligomers of the beta-amyloid (Abeta) peptide have been indicated in early neuropathologic changes in Alzheimer's disease. Here, we present a synthetic Abeta(20-42) oligomer (named globulomer) with a different conformation to monomeric and fibrillar Abeta peptide, enabling the generation of highly Abeta oligomer-specific monoclonal antibodies. The globulomer-derived antibodies specifically detect oligomeric but not monomeric or fibrillar Abeta in various Abeta preparations. The globulomer… CONTINUE READING
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